9MRT

Cryo-EM structure of the human TRPM4 channel in a calcium and PI(4,5)P2 bound open state

Summary for 9MRT

• Entry DOI: 10.2210/pdb9mrt/pdb
• Related: 9MT8 9MTA 9MTC
• EMDB information: 48563
• Descriptor: Transient receptor potential cation channel subfamily M member 4, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, CALCIUM ION (3 entities in total)
• Functional Keywords: trpm4, ion channel, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 542334.91

Authors

Teixeira-Duarte, C.M.,Jiang, Y. (deposition date: 2025-01-08, release date: 2025-10-29)

• Primary citation: Teixeira-Duarte, C.M.,Zeng, W.,Jiang, Y.; Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel; Nat.Struct.Mol.Biol., 2025; DOI: 10.1038/s41594-025-01705-3

Experimental method

ELECTRON MICROSCOPY (2.44 Å)