9MRT
Cryo-EM structure of the human TRPM4 channel in a calcium and PI(4,5)P2 bound open state
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 492 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 224 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Region: {"description":"Mediates modulation by decavanadate and PIP2-binding","evidences":[{"source":"PubMed","id":"16424899","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q7TN37","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B91","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B90","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B8Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B91","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B8W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B8Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"Q7TN37","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"15590641","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
