9MTC

Cryo-EM structure of the human TRPM4 channel in a ATP bound inhibited state

Summary for 9MTC

• Entry DOI: 10.2210/pdb9mtc/pdb
• Related: 9MRT 9MT8 9MTA
• EMDB information: 48563 48603 48604 48605
• Descriptor: Transient receptor potential cation channel subfamily M member 4, ADENOSINE-5'-TRIPHOSPHATE (2 entities in total)
• Functional Keywords: trpm4, ion channel, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 539854.66

Authors

Teixeira-Duarte, C.M.,Jiang, Y. (deposition date: 2025-01-10, release date: 2025-10-29)

• Primary citation: Teixeira-Duarte, C.M.,Zeng, W.,Jiang, Y.; Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel; Nat.Struct.Mol.Biol., 2025; DOI: 10.1038/s41594-025-01705-3

Experimental method

ELECTRON MICROSCOPY (2.63 Å)