9MPP

The cryo-EM structure of nucleosome-bound DNA methyltransferases DNMT3A2 and DNMT3L

Summary for 9MPP

Entry DOI	10.2210/pdb9mpp/pdb
Related	9MP0 9MPO
EMDB information	48494 48495 48496 48497 48498
Descriptor	Histone H3.2, S-ADENOSYL-L-HOMOCYSTEINE, Histone H4, ... (10 entities in total)
Functional Keywords	methyltransferase, dnmt-nucleosome complex, transferase, transferase-dna complex, dna binding protein
Biological source	Xenopus laevis (African clawed frog) More
Total number of polymer chains	14
Total formula weight	455838.66
Authors	Yan, Y.,Zhou, X.E.,Xu, T.H. (deposition date: 2024-12-31, release date: 2025-10-08)
Primary citation	Yan, Y.,Zhou, X.E.,Thomas, T.,Liu, M.,O'Leary, T.,Griffin, P.R.,Lai, G.,Worden, E.,Jones, P.A.,Xu, T.H. Structural Insights into DNMT3A-3L-Mediated de novo DNA Methylation on Chromatin To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation