9C50

Replacement of a single residue changes the primary specificity of thrombin

Summary for 9C50

Entry DOI	10.2210/pdb9c50/pdb
Descriptor	Thrombin A-chain, Thrombin B-chain, FPF, ... (5 entities in total)
Functional Keywords	coagulation, thrombin, blood clotting
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	71973.01
Authors	Dei Rossi, A.,Deavila, S.,Mohammed, B.M.,Korolev, S.,Di Cera, E. (deposition date: 2024-06-05, release date: 2025-01-22, Last modification date: 2025-04-16)
Primary citation	Dei Rossi, A.,Deavila, S.,Mohammed, B.M.,Korolev, S.,Di Cera, E. Replacement of a single residue changes the primary specificity of thrombin. J.Thromb.Haemost., 23:1241-1246, 2025 Cited by PubMed Abstract: Thrombin prefers substrates carrying Arg at the site of cleavage (P1) because of the presence of D189 in the primary specificity (S1) pocket but can also cleave substrates carrying Phe at P1. The structural basis of this property is unknown. PubMed: 39756655 DOI: 10.1016/j.jtha.2024.12.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation