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9C50

Replacement of a single residue changes the primary specificity of thrombin

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
Thrombin A-chainpolymer364096.52UniProt (P00734)
Pfam (PF09396)
Homo sapiens (human)Coagulation factor II
2B, D
(B, D)
Thrombin B-chainpolymer27331425.02UniProt (P00734)
Pfam (PF00089)
Homo sapiens (human)
3E, F
(E, F)
FPFpolymer3441.92synthetic construct
4G, H
(B, D)
SODIUM IONnon-polymer23.02Chemie (NA)
5I, J, K, L
(A, B, C, D)
waterwater18.0121Chemie (HOH)
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
PDBExternal DatabaseDetails
Tyr 248-expression tag
Leu 249-expression tag
Glu 250-expression tag
Asp 251-expression tag
Gln 252-expression tag
Val 253-expression tag
Asp 254-expression tag
Pro 255-expression tag
Arg 256-expression tag
Leu 257-expression tag
Ile 258-expression tag
Asp 259-expression tag
Gly 260-expression tag
Lys 261-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight71927.0
Non-Polymers*Number of molecules2
Total formula weight46.0
All*Total formula weight71973.0
*Water molecules are not included.

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PDB entries from 2025-08-06

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