8W7C

Activation of mitochondrial Caseinolytic Protease P (ClpP) induces selective cancer cell lethality

Summary for 8W7C

• Entry DOI: 10.2210/pdb8w7c/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, 11-[(3-chlorophenyl)methyl]-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),3,5-trien-8-one (2 entities in total)
• Functional Keywords: xt6, mitochondrial, clpp, activation, apoptosis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 7
• Total formula weight: 173578.26

Authors

Jiang, J.-X.,Ding, H.,Lu, M.-L.,Chen, M.-R.,Sun, H.-Y.,Xiao, Y.-B. (deposition date: 2023-08-30, release date: 2024-09-04)

• Primary citation: Jiang, J.-X.,Ding, H.,Lu, M.-L.,Chen, M.-R.,Sun, H.-Y.,Xiao, Y.-B.; Activation of mitochondrial Caseinolytic Protease P (ClpP) induces selective cancer cell lethality; To Be Published,

Experimental method

X-RAY DIFFRACTION (3 Å)