8W7C
Activation of mitochondrial Caseinolytic Protease P (ClpP) induces selective cancer cell lethality
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ATP-dependent Clp protease proteolytic subunit, mitochondrial | polymer | 223 | 24324.0 | 7 | UniProt (Q16740) Pfam (PF00574) | Homo sapiens (human) | Endopeptidase Clp |
| 2 | H, I, J, K, L... (A, B, C, D, E...) | 11-[(3-chlorophenyl)methyl]-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),3,5-trien-8-one | non-polymer | 472.9 | 7 | Chemie (R89) |
Sequence modifications
A, B, C, D, E, F, G: 58 - 277 (UniProt: Q16740)
| PDB | External Database | Details |
|---|---|---|
| Gly 55 | - | linker |
| Ser 56 | - | linker |
| Ser 57 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 170268.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3310.2 | |
| All* | Total formula weight | 173578.3 |
