8T6Z

Influenza PAN endonuclease I38T mutant with 6-(4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid

Summary for 8T6Z

Entry DOI	10.2210/pdb8t6z/pdb
Related	8T5V 8T5W 8T5Z 8T67
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, ... (4 entities in total)
Functional Keywords	influenza endonuclease, resistance, drug discovery, metal-binding pharmacophore, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Influenza A virus
Total number of polymer chains	1
Total formula weight	22889.61
Authors	Kohlbrand, A.J.,Cohen, S.M. (deposition date: 2023-06-19, release date: 2024-05-08)
Primary citation	Kohlbrand, A.J.,Stokes, R.W.,Sankaran, B.,Cohen, S.M. Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63:264-272, 2024 Cited by PubMed: 38190441 DOI: 10.1021/acs.biochem.3c00536 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation