8T5Z

Influenza PA-N Endonuclease (amino acids 52-74 truncation)

Summary for 8T5Z

• Entry DOI: 10.2210/pdb8t5z/pdb
• Related: 8T5V 8T5W
• Descriptor: Polymerase acidic protein, MANGANESE (II) ION (3 entities in total)
• Functional Keywords: influenza endonuclease, resistance, drug discovery, metal-binding pharmacophore, viral protein, hydrolase
• Biological source: Influenza A virus
• Total number of polymer chains: 1
• Total formula weight: 22534.42

Authors

Kohlbrand, A.J.,Cohen, S.M. (deposition date: 2023-06-14, release date: 2024-05-08)

• Primary citation: Kohlbrand, A.J.,Stokes, R.W.,Sankaran, B.,Cohen, S.M.; Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.; Biochemistry, 63:264-272, 2024; PubMed: 38190441; DOI: 10.1021/acs.biochem.3c00536

Experimental method

X-RAY DIFFRACTION (2.03 Å)