8T6Z
Influenza PAN endonuclease I38T mutant with 6-(4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Polymerase acidic protein | polymer | 192 | 22412.5 | 1 | UniProt (C3W5S0) In PDB | Influenza A virus | RNA-directed RNA polymerase subunit P2 |
2 | A | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
3 | A | (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid | non-polymer | 367.2 | 1 | Chemie (IJM) | |||
4 | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 1 - 198 (UniProt: C3W5S0)
PDB | External Database | Details |
---|---|---|
Met -5 | - | initiating methionine |
Gly -4 | - | expression tag |
Ser -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ala 0 | - | expression tag |
Thr 38 | Ile 38 | engineered mutation |
Gly 52 | His 52 | conflict |
- | Phe 53 | deletion |
- | Ile 54 | deletion |
- | Asp 55 | deletion |
- | Glu 56 | deletion |
- | Arg 57 | deletion |
- | Gly 58 | deletion |
- | Glu 59 | deletion |
- | Ser 60 | deletion |
- | Ile 61 | deletion |
- | Ile 62 | deletion |
- | Val 63 | deletion |
- | Glu 64 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 22412.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 477.1 | |
All* | Total formula weight | 22889.6 |