8T5W

Influenza PAN endonuclease I38T mutant with Baloxavir

Summary for 8T5W

Entry DOI	10.2210/pdb8t5w/pdb
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid, ... (4 entities in total)
Functional Keywords	influenza endonuclease, resistance, drug discovery, metal-binding pharmacophore, antiviral protein, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Influenza A virus (A/California/04/2009(H1N1))
Total number of polymer chains	1
Total formula weight	23489.34
Authors	Kohlbrand, A.J.,Cohen, S.M. (deposition date: 2023-06-14, release date: 2024-06-12)
Primary citation	Kohlbrand, A.J.,Stokes, R.W.,Sankaran, B.,Cohen, S.M. Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry, 63:264-272, 2024 Cited by PubMed: 38190441 DOI: 10.1021/acs.biochem.3c00536 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation