8SZY

Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT

Summary for 8SZY

• Entry DOI: 10.2210/pdb8szy/pdb
• Descriptor: CHA.9.543 Fab heavy chain, CHA.9.543 light chain, BMS-986207 Fab Heavy Chain, ... (7 entities in total)
• Functional Keywords: antibody, tigit, pvr-family, immune system, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 221157.78

Authors

Diong, S.J.,Lee, P.S. (deposition date: 2023-05-30, release date: 2023-09-20)

• Primary citation: Diong, S.J.,Jashnani, A.,Drake, A.W.,Bee, C.,Findeisen, F.,Dollinger, G.,Wang, F.,Rajpal, A.,Strop, P.,Lee, P.S.; Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT.; Mabs, 15:2253788-2253788, 2023; PubMed: 37675979; DOI: 10.1080/19420862.2023.2253788

Experimental method

X-RAY DIFFRACTION (2.31 Å)