8SZY

Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, C)	CHA.9.543 Fab heavy chain	polymer	228	24309.2	2		Homo sapiens (human)
2	B, G (B, D)	CHA.9.543 light chain	polymer	219	24072.8	2		Homo sapiens (human)
3	C, H (H, I)	BMS-986207 Fab Heavy Chain	polymer	241	25870.7	2		Homo sapiens (human)
4	D, I (L, M)	BMS-986207 light chain	polymer	216	23621.2	2		Homo sapiens (human)
5	E, J (T, U)	T-cell immunoreceptor with Ig and ITIM domains	polymer	114	12483.8	2	UniProt (Q495A1) Pfam (PF07686)	Homo sapiens (human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
6	K, L (T, U)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	M, N, O, P, Q... (A, B, H, L, T...)	water	water		18.0	112	Chemie (HOH)

Sequence modifications

T, U: 1 - 106 (UniProt: Q495A1)

PDB	External Database	Details
Ser 47	Cys 69	engineered mutation
Gly 107	-	expression tag
Gly 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	220715.4
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	221157.8

*Water molecules are not included.