8SZY

Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	CHA.9.543 Fab heavy chain	polymer	228	24309.2	2		Homo sapiens (human)
2	B, D	CHA.9.543 light chain	polymer	219	24072.8	2		Homo sapiens (human)
3	H, I	BMS-986207 Fab Heavy Chain	polymer	241	25870.7	2		Homo sapiens (human)
4	L, M	BMS-986207 light chain	polymer	216	23621.2	2		Homo sapiens (human)
5	T, U	T-cell immunoreceptor with Ig and ITIM domains	polymer	114	12483.8	2	UniProt (Q495A1) Pfam (PF07686) In PDB	Homo sapiens (human)	V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3
6	T, U	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7		water	water		18.0	112	Chemie (HOH)

Sequence modifications

T, U: 1 - 106 (UniProt: Q495A1)

PDB	External Database	Details
Ser 47	Cys 69	engineered mutation
Gly 107	-	expression tag
Gly 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	220715.4
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	221157.8

*Water molecules are not included.