8SZY

Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT

Functional Information from GO Data

Chain	GOid	namespace	contents
T	0005102	molecular_function	signaling receptor binding
T	0050868	biological_process	negative regulation of T cell activation
U	0005102	molecular_function	signaling receptor binding
U	0050868	biological_process	negative regulation of T cell activation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
A	TYR194-HIS200
H	TYR194-HIS200
B	TYR192-HIS198
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Region: {"description":"Homodimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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