8S0L

Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07

Summary for 8S0L

• Entry DOI: 10.2210/pdb8s0l/pdb
• Related: 8S0M 8S0N
• Descriptor: Transmembrane protease serine 2, Nanobody A07, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: protease, nanobody, inhibitor, zymogen, protein binding, protease-nanobody inhibitor complex, protease/nanobody inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 59970.97

Authors

Duquerroy, S.,Fernandez, I.,Rey, F. (deposition date: 2024-02-14, release date: 2024-06-26, Last modification date: 2024-09-04)

• Primary citation: Fernandez, I.,Saunders, N.,Duquerroy, S.,Bolland, W.H.,Arbabian, A.,Baquero, E.,Blanc, C.,Lafaye, P.,Haouz, A.,Buchrieser, J.,Schwartz, O.,Rey, F.A.; Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.; Cell, 187:4246-4260.e16, 2024; PubMed: 38964326; DOI: 10.1016/j.cell.2024.06.007

Experimental method

X-RAY DIFFRACTION (1.8 Å)