8S0L
Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transmembrane protease serine 2 | polymer | 395 | 43678.2 | 1 | UniProt (O15393) Pfam (PF15494) Pfam (PF00089) | Homo sapiens (human) | Serine protease 10 |
| 2 | B (B) | Nanobody A07 | polymer | 150 | 16031.5 | 1 | Vicugna pacos | ||
| 3 | C (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 401 | Chemie (HOH) |
Sequence modifications
A: 107 - 492 (UniProt: O15393)
| PDB | External Database | Details |
|---|---|---|
| Ala 441 | Ser 441 | engineered mutation |
| Gly 493 | - | expression tag |
| Pro 494 | - | expression tag |
| Phe 495 | - | expression tag |
| Glu 496 | - | expression tag |
| Asp 497 | - | expression tag |
| Asp 498 | - | expression tag |
| Asp 499 | - | expression tag |
| Asp 500 | - | expression tag |
| Lys 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59709.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 261.3 | |
| All* | Total formula weight | 59971.0 |
