8S0L
Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Transmembrane protease serine 2 | polymer | 395 | 43678.2 | 1 | UniProt (O15393) Pfam (PF15494) Pfam (PF00089) In PDB | Homo sapiens (human) | Serine protease 10 |
2 | B | Nanobody A07 | polymer | 150 | 16031.5 | 1 | Vicugna pacos | ||
3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
5 | water | water | 18.0 | 401 | Chemie (HOH) |
Sequence modifications
A: 107 - 492 (UniProt: O15393)
PDB | External Database | Details |
---|---|---|
Ala 441 | Ser 441 | engineered mutation |
Gly 493 | - | expression tag |
Pro 494 | - | expression tag |
Phe 495 | - | expression tag |
Glu 496 | - | expression tag |
Asp 497 | - | expression tag |
Asp 498 | - | expression tag |
Asp 499 | - | expression tag |
Asp 500 | - | expression tag |
Lys 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 59709.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 261.3 | |
All* | Total formula weight | 59971.0 |