8S0L

Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
A	VAL292-CYS297

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site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CInpsnw.CDgvsHCpgg.EDEnr...C

Chain	Residue	Details
A	CYS126-CYS148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:38964326

Chain	Residue	Details
A	HIS296

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:38964326

Chain	Residue	Details
A	ASP345
A	ALA441

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:37990007, ECO:0000269|PubMed:38964326, ECO:0007744|PDB:7XYD, ECO:0007744|PDB:7Y0E, ECO:0007744|PDB:7Y0F, ECO:0007744|PDB:8HD8, ECO:0007744|PDB:8S0L

Chain	Residue	Details
A	ASN131
A	ASP134
A	VAL136
A	ASP144
A	GLU145

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:38964328

Chain	Residue	Details
A	ARG255

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:37990007, ECO:0000269|PubMed:38964326, ECO:0007744|PDB:7XYD, ECO:0007744|PDB:7Y0E, ECO:0007744|PDB:7Y0F, ECO:0007744|PDB:8HD8, ECO:0007744|PDB:8S0L, ECO:0007744|PDB:8S0M

Chain	Residue	Details
A	ASN213

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN249

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