8S0M

Crystal structure of the HKU1 receptor binding domain in complex with TMPRSS2 and the nanobody A01

Summary for 8S0M

• Entry DOI: 10.2210/pdb8s0m/pdb
• Related: 8S0L 8S0N
• Descriptor: Transmembrane protease serine 2, Nanobody A01, Spike protein S1, ... (7 entities in total)
• Functional Keywords: coronavirus receptor, viral protein, protease, nanobody, viral protein-receptor complex, viral protein/receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 200449.90

Authors

Duquerroy, S.,Fernandez, I.,Rey, F. (deposition date: 2024-02-14, release date: 2024-06-26, Last modification date: 2024-09-04)

• Primary citation: Fernandez, I.,Saunders, N.,Duquerroy, S.,Bolland, W.H.,Arbabian, A.,Baquero, E.,Blanc, C.,Lafaye, P.,Haouz, A.,Buchrieser, J.,Schwartz, O.,Rey, F.A.; Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.; Cell, 187:4246-4260.e16, 2024; PubMed: 38964326; DOI: 10.1016/j.cell.2024.06.007

Experimental method

X-RAY DIFFRACTION (3.55 Å)