8QZZ

Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452

8QZZ の概要

• エントリーDOI: 10.2210/pdb8qzz/pdb
• 分子名称: Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 subunit 1, Protein phosphatase 1 regulatory subunit 15A, ... (4 entities in total)
• 機能のキーワード: eukaryotic initiation factor-2, pp1 regulatory subunit, dephosphorylation, metabolism, translation
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 91549.53

構造登録者

Yan, Y.,Ron, D. (登録日: 2023-10-30, 公開日: 2024-03-20, 最終更新日: 2024-04-10)

• 主引用文献: Yan, Y.,Shetty, M.,Harding, H.P.,George, G.,Zyryanova, A.,Labbe, K.,Mafi, A.,Hao, Q.,Sidrauski, C.,Ron, D.; Substrate recruitment via eIF2 gamma enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.; Proc.Natl.Acad.Sci.USA, 121:e2320013121-e2320013121, 2024; PubMed: 38547060; DOI: 10.1073/pnas.2320013121

実験手法

X-RAY DIFFRACTION (3.35 Å)