8DFG

Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19

Summary for 8DFG

Entry DOI	10.2210/pdb8dfg/pdb
Descriptor	42D6 Fab Heavy Chain, 42D6 Fab Light Chain, Merozoite surface protein 1, ... (4 entities in total)
Functional Keywords	merozoite surface protein 1 (msp1), antigen-antibody complex, plasmodium falciparum, antigenic diversion, structural protein-immune system complex, structural protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	123323.28
Authors	Patel, P.N.,Tang, W.K.,Tolia, N.H. (deposition date: 2022-06-22, release date: 2022-10-12, Last modification date: 2023-10-18)
Primary citation	Patel, P.N.,Dickey, T.H.,Hopp, C.S.,Diouf, A.,Tang, W.K.,Long, C.A.,Miura, K.,Crompton, P.D.,Tolia, N.H. Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion. Nat Commun, 13:5888-5888, 2022 Cited by PubMed: 36202833 DOI: 10.1038/s41467-022-33336-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation