8BW9
Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP
Summary for 8BW9
Entry DOI | 10.2210/pdb8bw9/pdb |
Related | 8BW8 |
EMDB information | 16281 |
Descriptor | Protein aveugle, Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, ... (7 entities in total) |
Functional Keywords | kinase suppressor of ras (ksr), dual specificity mitogen-activated protein kinase kinase (mek), connector enhancer of ksr (cnk), protein aveugle (ave), hyphen protein (hyp), protein complex, signaling protein |
Biological source | Drosophila melanogaster (fruit fly) More |
Total number of polymer chains | 4 |
Total formula weight | 133225.40 |
Authors | Maisonneuve, P.,Fronzes, R.,Sicheri, F. (deposition date: 2022-12-06, release date: 2024-02-21, Last modification date: 2024-07-31) |
Primary citation | Maisonneuve, P.,Sahmi, M.,Bergeron-Labrecque, F.,Ma, X.I.,Queguiner, J.,Arseneault, G.,Lefrancois, M.,Kurinov, I.,Fronzes, R.,Sicheri, F.,Therrien, M. The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nat.Struct.Mol.Biol., 31:1028-1038, 2024 Cited by PubMed: 38388830DOI: 10.1038/s41594-024-01233-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.32 Å) |
Structure validation
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