8BR0

ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin (residue Q3455 to L3863) in complex with 3'deoxyCTP and two manganese cations bound to Latrunculin-B-ADP-Mn-actin

8BR0 の概要

• エントリーDOI: 10.2210/pdb8br0/pdb
• 関連するPDBエントリー: 8BJH 8BJI 8BJJ 8BO1
• 分子名称: Actin, alpha skeletal muscle, intermediate form, Putative Adenylate cyclase,Profilin-1, LATRUNCULIN B, ... (7 entities in total)
• 機能のキーワード: bacterial nucleotidyl cyclase toxin, activated complex, toxin
• 由来する生物種: Vibrio nigripulchritudo SFn135; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 217100.31

構造登録者

Texeira-Nuns, M.,Retailleau, P.,Renault, L. (登録日: 2022-11-22, 公開日: 2023-09-20, 最終更新日: 2023-10-04)

• 主引用文献: Teixeira-Nunes, M.,Retailleau, P.,Raoux-Barbot, D.,Comisso, M.,Missinou, A.A.,Velours, C.,Plancqueel, S.,Ladant, D.,Mechold, U.,Renault, L.; Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.; Plos Pathog., 19:e1011654-e1011654, 2023; PubMed: 37747912; DOI: 10.1371/journal.ppat.1011654

実験手法

X-RAY DIFFRACTION (2.218 Å)