8FFE
Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide
Summary for 8FFE
Entry DOI | 10.2210/pdb8ffe/pdb |
Related | 8CTG |
EMDB information | 26989 |
Descriptor | Low-density lipoprotein receptor-related protein 6, YW210.09 Fab heavy chain with engineered XWnt8 NC peptide and linker, YW210.09 Fab light chain, ... (10 entities in total) |
Functional Keywords | wnt, receptor, lrp5, lrp6, ldl receptor-like protein, ywtd b-propeller, signaling protein, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 125399.74 |
Authors | Jude, K.M.,Tsutsumi, N.,Waghray, D.,Garcia, K.C. (deposition date: 2022-12-08, release date: 2023-03-08, Last modification date: 2023-03-22) |
Primary citation | Tsutsumi, N.,Hwang, S.,Waghray, D.,Hansen, S.,Jude, K.M.,Wang, N.,Miao, Y.,Glassman, C.R.,Caveney, N.A.,Janda, C.Y.,Hannoush, R.N.,Garcia, K.C. Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120:e2218238120-e2218238120, 2023 Cited by PubMed: 36893265DOI: 10.1073/pnas.2218238120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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