7ZKX

SRPK2 IN COMPLEX WITH INHIBITOR

Summary for 7ZKX

• Entry DOI: 10.2210/pdb7zkx/pdb
• Related: 7ZKS
• Descriptor: SRSF protein kinase 2, N-[3-[[[2-(6-chloranyl-5-fluoranyl-1H-benzimidazol-2-yl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-methyl-methanesulfonamide, SULFATE ION, ... (7 entities in total)
• Functional Keywords: serine/threonine-protein kinase, srpk2, nuclear protein, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 71518.03

Authors

Graedler, U. (deposition date: 2022-04-13, release date: 2023-02-22, Last modification date: 2024-02-07)

• Primary citation: Schroder, M.,Leiendecker, M.,Gradler, U.,Braun, J.,Blum, A.,Wanior, M.,Berger, B.T.,Kramer, A.,Muller, S.,Esdar, C.,Knapp, S.,Heinrich, T.; MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.; J.Med.Chem., 66:837-854, 2023; PubMed: 36516476; DOI: 10.1021/acs.jmedchem.2c01705

Experimental method

X-RAY DIFFRACTION (2.06 Å)