7ZKX

SRPK2 IN COMPLEX WITH INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000245	biological_process	spliceosomal complex assembly
A	0000287	molecular_function	magnesium ion binding
A	0000785	cellular_component	chromatin
A	0001525	biological_process	angiogenesis
A	0003723	molecular_function	RNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008380	biological_process	RNA splicing
A	0010468	biological_process	regulation of gene expression
A	0010628	biological_process	positive regulation of gene expression
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0030154	biological_process	cell differentiation
A	0035063	biological_process	nuclear speck organization
A	0035556	biological_process	intracellular signal transduction
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0045070	biological_process	positive regulation of viral genome replication
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045787	biological_process	positive regulation of cell cycle
A	0048024	biological_process	regulation of mRNA splicing, via spliceosome
A	0050684	biological_process	regulation of mRNA processing
A	0062176	biological_process	R-loop processing
A	0071889	molecular_function	14-3-3 protein binding
A	0106310	molecular_function	protein serine kinase activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlCwdmqgkrf..........VAMK

Chain	Residue	Details
A	LEU98-LYS121

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHtDIKpeNILM

Chain	Residue	Details
A	ILE221-MET233

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UPE1","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Cleavage; by caspase-3","evidences":[{"source":"PubMed","id":"21056976","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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