7ZKX
SRPK2 IN COMPLEX WITH INHIBITOR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000245 | biological_process | spliceosomal complex assembly |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000785 | cellular_component | chromatin |
| A | 0001525 | biological_process | angiogenesis |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008380 | biological_process | RNA splicing |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0018105 | biological_process | peptidyl-serine phosphorylation |
| A | 0030154 | biological_process | cell differentiation |
| A | 0035063 | biological_process | nuclear speck organization |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0043525 | biological_process | positive regulation of neuron apoptotic process |
| A | 0044024 | molecular_function | histone H2AS1 kinase activity |
| A | 0045070 | biological_process | positive regulation of viral genome replication |
| A | 0045071 | biological_process | negative regulation of viral genome replication |
| A | 0045087 | biological_process | innate immune response |
| A | 0045787 | biological_process | positive regulation of cell cycle |
| A | 0048024 | biological_process | regulation of mRNA splicing, via spliceosome |
| A | 0050684 | biological_process | regulation of mRNA processing |
| A | 0062176 | biological_process | R-loop processing |
| A | 0071889 | molecular_function | 14-3-3 protein binding |
| A | 0098793 | cellular_component | presynapse |
| A | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlCwdmqgkrf..........VAMK |
| Chain | Residue | Details |
| A | LEU98-LYS121 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHtDIKpeNILM |
| Chain | Residue | Details |
| A | ILE221-MET233 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP225 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9UPE1, ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU98 | |
| A | LYS121 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:21056976 |
| Chain | Residue | Details |
| A | ASP150 | |
| A | ASP414 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER391 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O54781 |
| Chain | Residue | Details |
| A | SER486 | |
| A | SER495 | |
| A | SER497 | |
| A | SER501 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O54781 |
| Chain | Residue | Details |
| A | THR489 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:19592491 |
| Chain | Residue | Details |
| A | THR503 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER505 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER508 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000250 |
| Chain | Residue | Details |
| A | SER599 |
