7THO

Integrin alaphIIBbeta3 complex with Eptifibatide

Summary for 7THO

Entry DOI	10.2210/pdb7tho/pdb
Related	7TCT 7TD8
Related PRD ID	PRD_002490
Descriptor	Integrin alpha-IIb, SULFATE ION, MAGNESIUM ION, ... (13 entities in total)
Functional Keywords	complex, inhibitor, blood clotting, blood clotting-inhibitor complex, blood clotting/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	300924.51
Authors	Zhu, J.,Lin, F.-Y.,Zhu, J.,Springer, T.A. (deposition date: 2022-01-11, release date: 2022-08-17, Last modification date: 2023-11-15)
Primary citation	Lin, F.Y.,Li, J.,Xie, Y.,Zhu, J.,Huong Nguyen, T.T.,Zhang, Y.,Zhu, J.,Springer, T.A. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185:3533-3550.e27, 2022 Cited by PubMed: 36113427 DOI: 10.1016/j.cell.2022.08.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation