7RBS
The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with human ISG15
Summary for 7RBS
Entry DOI | 10.2210/pdb7rbs/pdb |
Descriptor | Papain-like protease, Ubiquitin-like protein ISG15, ZINC ION, ... (4 entities in total) |
Functional Keywords | covid-19, coronavirus, sars, cov-2, papain-like protease, isg15, idp51000, idp52003, center for structural genomics of infectious diseases, csgid, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 10 |
Total formula weight | 266489.34 |
Authors | Osipiuk, J.,Tesar, C.,Jedrzejczak, R.,Endres, M.,Wydorski, P.,Joachimiak, L.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2021-07-06, release date: 2021-09-29, Last modification date: 2023-10-25) |
Primary citation | Wydorski, P.M.,Osipiuk, J.,Lanham, B.T.,Tesar, C.,Endres, M.,Engle, E.,Jedrzejczak, R.,Mullapudi, V.,Michalska, K.,Fidelis, K.,Fushman, D.,Joachimiak, A.,Joachimiak, L.A. Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin. Nat Commun, 14:2366-2366, 2023 Cited by PubMed: 37185902DOI: 10.1038/s41467-023-38031-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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