7RBS

The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with human ISG15

Summary for 7RBS

• Entry DOI: 10.2210/pdb7rbs/pdb
• Descriptor: Papain-like protease, Ubiquitin-like protein ISG15, ZINC ION, ... (4 entities in total)
• Functional Keywords: covid-19, coronavirus, sars, cov-2, papain-like protease, isg15, idp51000, idp52003, center for structural genomics of infectious diseases, csgid, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 10
• Total formula weight: 266489.34

Authors

Osipiuk, J.,Tesar, C.,Jedrzejczak, R.,Endres, M.,Wydorski, P.,Joachimiak, L.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2021-07-06, release date: 2021-09-29, Last modification date: 2023-10-25)

• Primary citation: Wydorski, P.M.,Osipiuk, J.,Lanham, B.T.,Tesar, C.,Endres, M.,Engle, E.,Jedrzejczak, R.,Mullapudi, V.,Michalska, K.,Fidelis, K.,Fushman, D.,Joachimiak, A.,Joachimiak, L.A.; Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.; Nat Commun, 14:2366-2366, 2023; PubMed: 37185902; DOI: 10.1038/s41467-023-38031-5

Experimental method

X-RAY DIFFRACTION (2.98 Å)