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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7RBS

The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with human ISG15

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0002376biological_processimmune system process
B0002682biological_processregulation of immune system process
B0003735molecular_functionstructural constituent of ribosome
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007229biological_processintegrin-mediated signaling pathway
B0009615biological_processresponse to virus
B0019941biological_processmodification-dependent protein catabolic process
B0022626cellular_componentcytosolic ribosome
B0030501biological_processpositive regulation of bone mineralization
B0031386molecular_functionprotein tag activity
B0031397biological_processnegative regulation of protein ubiquitination
B0032020biological_processISG15-protein conjugation
B0032461biological_processpositive regulation of protein oligomerization
B0032649biological_processregulation of type II interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0032729biological_processpositive regulation of type II interferon production
B0032733biological_processpositive regulation of interleukin-10 production
B0034340biological_processresponse to type I interferon
B0042742biological_processdefense response to bacterium
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0045648biological_processpositive regulation of erythrocyte differentiation
B0051240biological_processpositive regulation of multicellular organismal process
B0051607biological_processdefense response to virus
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0070585biological_processprotein localization to mitochondrion
C0006508biological_processproteolysis
C0008234molecular_functioncysteine-type peptidase activity
D0002376biological_processimmune system process
D0002682biological_processregulation of immune system process
D0003735molecular_functionstructural constituent of ribosome
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007229biological_processintegrin-mediated signaling pathway
D0009615biological_processresponse to virus
D0019941biological_processmodification-dependent protein catabolic process
D0022626cellular_componentcytosolic ribosome
D0030501biological_processpositive regulation of bone mineralization
D0031386molecular_functionprotein tag activity
D0031397biological_processnegative regulation of protein ubiquitination
D0032020biological_processISG15-protein conjugation
D0032461biological_processpositive regulation of protein oligomerization
D0032649biological_processregulation of type II interferon production
D0032728biological_processpositive regulation of interferon-beta production
D0032729biological_processpositive regulation of type II interferon production
D0032733biological_processpositive regulation of interleukin-10 production
D0034340biological_processresponse to type I interferon
D0042742biological_processdefense response to bacterium
D0045071biological_processnegative regulation of viral genome replication
D0045087biological_processinnate immune response
D0045648biological_processpositive regulation of erythrocyte differentiation
D0051240biological_processpositive regulation of multicellular organismal process
D0051607biological_processdefense response to virus
D0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
D0070585biological_processprotein localization to mitochondrion
E0006508biological_processproteolysis
E0008234molecular_functioncysteine-type peptidase activity
F0002376biological_processimmune system process
F0002682biological_processregulation of immune system process
F0003735molecular_functionstructural constituent of ribosome
F0005178molecular_functionintegrin binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0007229biological_processintegrin-mediated signaling pathway
F0009615biological_processresponse to virus
F0019941biological_processmodification-dependent protein catabolic process
F0022626cellular_componentcytosolic ribosome
F0030501biological_processpositive regulation of bone mineralization
F0031386molecular_functionprotein tag activity
F0031397biological_processnegative regulation of protein ubiquitination
F0032020biological_processISG15-protein conjugation
F0032461biological_processpositive regulation of protein oligomerization
F0032649biological_processregulation of type II interferon production
F0032728biological_processpositive regulation of interferon-beta production
F0032729biological_processpositive regulation of type II interferon production
F0032733biological_processpositive regulation of interleukin-10 production
F0034340biological_processresponse to type I interferon
F0042742biological_processdefense response to bacterium
F0045071biological_processnegative regulation of viral genome replication
F0045087biological_processinnate immune response
F0045648biological_processpositive regulation of erythrocyte differentiation
F0051240biological_processpositive regulation of multicellular organismal process
F0051607biological_processdefense response to virus
F0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
F0070585biological_processprotein localization to mitochondrion
G0006508biological_processproteolysis
G0008234molecular_functioncysteine-type peptidase activity
H0002376biological_processimmune system process
H0002682biological_processregulation of immune system process
H0003735molecular_functionstructural constituent of ribosome
H0005178molecular_functionintegrin binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0007229biological_processintegrin-mediated signaling pathway
H0009615biological_processresponse to virus
H0019941biological_processmodification-dependent protein catabolic process
H0022626cellular_componentcytosolic ribosome
H0030501biological_processpositive regulation of bone mineralization
H0031386molecular_functionprotein tag activity
H0031397biological_processnegative regulation of protein ubiquitination
H0032020biological_processISG15-protein conjugation
H0032461biological_processpositive regulation of protein oligomerization
H0032649biological_processregulation of type II interferon production
H0032728biological_processpositive regulation of interferon-beta production
H0032729biological_processpositive regulation of type II interferon production
H0032733biological_processpositive regulation of interleukin-10 production
H0034340biological_processresponse to type I interferon
H0042742biological_processdefense response to bacterium
H0045071biological_processnegative regulation of viral genome replication
H0045087biological_processinnate immune response
H0045648biological_processpositive regulation of erythrocyte differentiation
H0051240biological_processpositive regulation of multicellular organismal process
H0051607biological_processdefense response to virus
H0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
H0070585biological_processprotein localization to mitochondrion
I0006508biological_processproteolysis
I0008234molecular_functioncysteine-type peptidase activity
J0002376biological_processimmune system process
J0002682biological_processregulation of immune system process
J0003735molecular_functionstructural constituent of ribosome
J0005178molecular_functionintegrin binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0007229biological_processintegrin-mediated signaling pathway
J0009615biological_processresponse to virus
J0019941biological_processmodification-dependent protein catabolic process
J0022626cellular_componentcytosolic ribosome
J0030501biological_processpositive regulation of bone mineralization
J0031386molecular_functionprotein tag activity
J0031397biological_processnegative regulation of protein ubiquitination
J0032020biological_processISG15-protein conjugation
J0032461biological_processpositive regulation of protein oligomerization
J0032649biological_processregulation of type II interferon production
J0032728biological_processpositive regulation of interferon-beta production
J0032729biological_processpositive regulation of type II interferon production
J0032733biological_processpositive regulation of interleukin-10 production
J0034340biological_processresponse to type I interferon
J0042742biological_processdefense response to bacterium
J0045071biological_processnegative regulation of viral genome replication
J0045087biological_processinnate immune response
J0045648biological_processpositive regulation of erythrocyte differentiation
J0051240biological_processpositive regulation of multicellular organismal process
J0051607biological_processdefense response to virus
J0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
J0070585biological_processprotein localization to mitochondrion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues185
DetailsZinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues5
DetailsActive site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32726803","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues10
DetailsActive site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues610
DetailsDomain: {"description":"Ubiquitin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues110
DetailsRepeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues380
DetailsDomain: {"description":"Ubiquitin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsRegion: {"description":"Involved in the ligation of specific target proteins","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues25
DetailsMotif: {"description":"LRLRGG"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues5
DetailsSite: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues5
DetailsModified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"PubMed","id":"18606809","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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