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7RBS

The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with human ISG15

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0002376biological_processimmune system process
B0002682biological_processregulation of immune system process
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007229biological_processintegrin-mediated signaling pathway
B0009615biological_processresponse to virus
B0009617biological_processresponse to bacterium
B0016567biological_processprotein ubiquitination
B0019941biological_processmodification-dependent protein catabolic process
B0030501biological_processpositive regulation of bone mineralization
B0031386molecular_functionprotein tag activity
B0031397biological_processnegative regulation of protein ubiquitination
B0031625molecular_functionubiquitin protein ligase binding
B0032020biological_processISG15-protein conjugation
B0032461biological_processpositive regulation of protein oligomerization
B0032649biological_processregulation of type II interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0032729biological_processpositive regulation of type II interferon production
B0032733biological_processpositive regulation of interleukin-10 production
B0034340biological_processresponse to type I interferon
B0042742biological_processdefense response to bacterium
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0045648biological_processpositive regulation of erythrocyte differentiation
B0051240biological_processpositive regulation of multicellular organismal process
B0051607biological_processdefense response to virus
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0070585biological_processprotein localization to mitochondrion
C0006508biological_processproteolysis
C0008234molecular_functioncysteine-type peptidase activity
D0002376biological_processimmune system process
D0002682biological_processregulation of immune system process
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007229biological_processintegrin-mediated signaling pathway
D0009615biological_processresponse to virus
D0009617biological_processresponse to bacterium
D0016567biological_processprotein ubiquitination
D0019941biological_processmodification-dependent protein catabolic process
D0030501biological_processpositive regulation of bone mineralization
D0031386molecular_functionprotein tag activity
D0031397biological_processnegative regulation of protein ubiquitination
D0031625molecular_functionubiquitin protein ligase binding
D0032020biological_processISG15-protein conjugation
D0032461biological_processpositive regulation of protein oligomerization
D0032649biological_processregulation of type II interferon production
D0032728biological_processpositive regulation of interferon-beta production
D0032729biological_processpositive regulation of type II interferon production
D0032733biological_processpositive regulation of interleukin-10 production
D0034340biological_processresponse to type I interferon
D0042742biological_processdefense response to bacterium
D0045071biological_processnegative regulation of viral genome replication
D0045087biological_processinnate immune response
D0045648biological_processpositive regulation of erythrocyte differentiation
D0051240biological_processpositive regulation of multicellular organismal process
D0051607biological_processdefense response to virus
D0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
D0070585biological_processprotein localization to mitochondrion
E0006508biological_processproteolysis
E0008234molecular_functioncysteine-type peptidase activity
F0002376biological_processimmune system process
F0002682biological_processregulation of immune system process
F0005178molecular_functionintegrin binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0007229biological_processintegrin-mediated signaling pathway
F0009615biological_processresponse to virus
F0009617biological_processresponse to bacterium
F0016567biological_processprotein ubiquitination
F0019941biological_processmodification-dependent protein catabolic process
F0030501biological_processpositive regulation of bone mineralization
F0031386molecular_functionprotein tag activity
F0031397biological_processnegative regulation of protein ubiquitination
F0031625molecular_functionubiquitin protein ligase binding
F0032020biological_processISG15-protein conjugation
F0032461biological_processpositive regulation of protein oligomerization
F0032649biological_processregulation of type II interferon production
F0032728biological_processpositive regulation of interferon-beta production
F0032729biological_processpositive regulation of type II interferon production
F0032733biological_processpositive regulation of interleukin-10 production
F0034340biological_processresponse to type I interferon
F0042742biological_processdefense response to bacterium
F0045071biological_processnegative regulation of viral genome replication
F0045087biological_processinnate immune response
F0045648biological_processpositive regulation of erythrocyte differentiation
F0051240biological_processpositive regulation of multicellular organismal process
F0051607biological_processdefense response to virus
F0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
F0070585biological_processprotein localization to mitochondrion
G0006508biological_processproteolysis
G0008234molecular_functioncysteine-type peptidase activity
H0002376biological_processimmune system process
H0002682biological_processregulation of immune system process
H0005178molecular_functionintegrin binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0007229biological_processintegrin-mediated signaling pathway
H0009615biological_processresponse to virus
H0009617biological_processresponse to bacterium
H0016567biological_processprotein ubiquitination
H0019941biological_processmodification-dependent protein catabolic process
H0030501biological_processpositive regulation of bone mineralization
H0031386molecular_functionprotein tag activity
H0031397biological_processnegative regulation of protein ubiquitination
H0031625molecular_functionubiquitin protein ligase binding
H0032020biological_processISG15-protein conjugation
H0032461biological_processpositive regulation of protein oligomerization
H0032649biological_processregulation of type II interferon production
H0032728biological_processpositive regulation of interferon-beta production
H0032729biological_processpositive regulation of type II interferon production
H0032733biological_processpositive regulation of interleukin-10 production
H0034340biological_processresponse to type I interferon
H0042742biological_processdefense response to bacterium
H0045071biological_processnegative regulation of viral genome replication
H0045087biological_processinnate immune response
H0045648biological_processpositive regulation of erythrocyte differentiation
H0051240biological_processpositive regulation of multicellular organismal process
H0051607biological_processdefense response to virus
H0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
H0070585biological_processprotein localization to mitochondrion
I0006508biological_processproteolysis
I0008234molecular_functioncysteine-type peptidase activity
J0002376biological_processimmune system process
J0002682biological_processregulation of immune system process
J0005178molecular_functionintegrin binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0007229biological_processintegrin-mediated signaling pathway
J0009615biological_processresponse to virus
J0009617biological_processresponse to bacterium
J0016567biological_processprotein ubiquitination
J0019941biological_processmodification-dependent protein catabolic process
J0030501biological_processpositive regulation of bone mineralization
J0031386molecular_functionprotein tag activity
J0031397biological_processnegative regulation of protein ubiquitination
J0031625molecular_functionubiquitin protein ligase binding
J0032020biological_processISG15-protein conjugation
J0032461biological_processpositive regulation of protein oligomerization
J0032649biological_processregulation of type II interferon production
J0032728biological_processpositive regulation of interferon-beta production
J0032729biological_processpositive regulation of type II interferon production
J0032733biological_processpositive regulation of interleukin-10 production
J0034340biological_processresponse to type I interferon
J0042742biological_processdefense response to bacterium
J0045071biological_processnegative regulation of viral genome replication
J0045087biological_processinnate immune response
J0045648biological_processpositive regulation of erythrocyte differentiation
J0051240biological_processpositive regulation of multicellular organismal process
J0051607biological_processdefense response to virus
J0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
J0070585biological_processprotein localization to mitochondrion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsSITE: Interacts with activating enzyme => ECO:0000250
ChainResidueDetails
BARG153
DARG153
FARG153
HARG153
JARG153

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: S-nitrosocysteine; alternate => ECO:0000269|PubMed:18606809
ChainResidueDetails
BCYS78
DCYS78
FCYS78
HCYS78
JCYS78

site_idSWS_FT_FI3
Number of Residues10
DetailsCROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214
ChainResidueDetails
BGLY157
IASP286
AASP286
DGLY157
CASP286
FGLY157
EASP286
HGLY157
GASP286
JGLY157

site_idSWS_FT_FI4
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444
ChainResidueDetails
ACYS189
ECYS192
ECYS224
ECYS226
GCYS189
GCYS192
GCYS224
GCYS226
ICYS189
ICYS192
ICYS224
ACYS192
ICYS226
ACYS224
ACYS226
CCYS189
CCYS192
CCYS224
CCYS226
ECYS189

237992

PDB entries from 2025-06-25

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