7RBS
The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with human ISG15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I (A, C, E, G, I) | Papain-like protease | polymer | 318 | 35927.7 | 5 | UniProt (P0DTC1) Pfam (PF08715) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Non-structural protein 3, nsp3, PL2-PRO, Papain-like proteinase, PL-PRO |
| 2 | B, D, F, H, J (B, D, F, H, J) | Ubiquitin-like protein ISG15 | polymer | 159 | 17304.8 | 5 | UniProt (P05161) Pfam (PF00240) | Homo sapiens (Human) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP |
| 3 | K, L, M, N, O (A, C, E, G, I) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 4 | P, Q, R, S, T... (A, B, C, D, E...) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I: 1 - 315 (UniProt: P0DTC1)
B, D, F, H, J: 2 - 157 (UniProt: P05161)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ser 111 | Cys 1674 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 266162.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 327.0 | |
| All* | Total formula weight | 266489.3 |
