7QPJ
Crystal structure of engineered TCR (756) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Summary for 7QPJ
Entry DOI | 10.2210/pdb7qpj/pdb |
Related | 7PBC 7PDW 7PDX |
Descriptor | MHC class I antigen, Beta-2-microglobulin, Melanoma-associated antigen 10, ... (7 entities in total) |
Functional Keywords | t-cell receptor, human leukocyte antigen, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 95289.79 |
Authors | Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J. (deposition date: 2022-01-04, release date: 2022-08-03, Last modification date: 2024-01-31) |
Primary citation | Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J. Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy. J Immunother Cancer, 10:-, 2022 Cited by PubMed: 35851311DOI: 10.1136/jitc-2022-004600 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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