7KXB
Crystal structure of SARS-CoV-2 Nsp3 Macrodomain complex with PARG329
Summary for 7KXB
Entry DOI | 10.2210/pdb7kxb/pdb |
Related | 7KFP 7KG0 7KG1 7KG3 7KG6 7KG7 7KG8 |
Descriptor | Non-structural protein 3, N-{3-[(1,3-dimethyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl)sulfanyl]propyl}-N'-[2-(morpholin-4-yl)ethyl]thiourea, BETA-MERCAPTOETHANOL, ... (5 entities in total) |
Functional Keywords | hydrolase, sars-cov-2, macrodomain |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 1 |
Total formula weight | 18922.55 |
Authors | Arvai, A.,Brosey, C.A.,Bommagani, S.,Link, T.,Jones, D.E.,Ahmed, Z.,Tainer, J.A. (deposition date: 2020-12-03, release date: 2021-02-17, Last modification date: 2023-10-18) |
Primary citation | Brosey, C.A.,Houl, J.H.,Katsonis, P.,Balapiti-Modarage, L.P.F.,Bommagani, S.,Arvai, A.,Moiani, D.,Bacolla, A.,Link, T.,Warden, L.S.,Lichtarge, O.,Jones, D.E.,Ahmed, Z.,Tainer, J.A. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163:171-186, 2021 Cited by PubMed: 33636189DOI: 10.1016/j.pbiomolbio.2021.02.002 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report