7KXB

Crystal structure of SARS-CoV-2 Nsp3 Macrodomain complex with PARG329

Summary for 7KXB

Entry DOI	10.2210/pdb7kxb/pdb
Related	7KFP 7KG0 7KG1 7KG3 7KG6 7KG7 7KG8
Descriptor	Non-structural protein 3, N-{3-[(1,3-dimethyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl)sulfanyl]propyl}-N'-[2-(morpholin-4-yl)ethyl]thiourea, BETA-MERCAPTOETHANOL, ... (5 entities in total)
Functional Keywords	hydrolase, sars-cov-2, macrodomain
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains	1
Total formula weight	18922.55
Authors	Arvai, A.,Brosey, C.A.,Bommagani, S.,Link, T.,Jones, D.E.,Ahmed, Z.,Tainer, J.A. (deposition date: 2020-12-03, release date: 2021-02-17, Last modification date: 2023-10-18)
Primary citation	Brosey, C.A.,Houl, J.H.,Katsonis, P.,Balapiti-Modarage, L.P.F.,Bommagani, S.,Arvai, A.,Moiani, D.,Bacolla, A.,Link, T.,Warden, L.S.,Lichtarge, O.,Jones, D.E.,Ahmed, Z.,Tainer, J.A. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163:171-186, 2021 Cited by PubMed: 33636189 DOI: 10.1016/j.pbiomolbio.2021.02.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation