7KG0

Structure of human PARG complexed with PARG-131

Summary for 7KG0

• Entry DOI: 10.2210/pdb7kg0/pdb
• Related: 7KFP 7KG1 7KG3 7KG6 7KG7 7KG8
• Descriptor: Poly(ADP-ribose) glycohydrolase, 5-({4-[(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)methyl]phenyl}methyl)pyrimidine-2,4,6(1H,3H,5H)-trione, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: hydrolase, hydrolase inhibitor complex, methyl xanthine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 61877.08

Authors

Arvai, A.,Bommagani, S.,Brosey, C.A.,Jones, D.E.,Warden, L.S.,Ahmed, Z.,Tainer, J.A. (deposition date: 2020-10-15, release date: 2021-03-10, Last modification date: 2023-10-18)

• Primary citation: Brosey, C.A.,Houl, J.H.,Katsonis, P.,Balapiti-Modarage, L.P.F.,Bommagani, S.,Arvai, A.,Moiani, D.,Bacolla, A.,Link, T.,Warden, L.S.,Lichtarge, O.,Jones, D.E.,Ahmed, Z.,Tainer, J.A.; Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.; Prog.Biophys.Mol.Biol., 163:171-186, 2021; PubMed: 33636189; DOI: 10.1016/j.pbiomolbio.2021.02.002

Experimental method

X-RAY DIFFRACTION (1.66 Å)