7KMA

Crystal structure of eif2Balpha with a ligand.

7KMA の概要

• エントリーDOI: 10.2210/pdb7kma/pdb
• 関連するPDBエントリー: 3ECS
• 分子名称: Translation initiation factor eIF-2B subunit alpha, 6-O-phosphono-alpha-D-mannopyranose, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: translation initiation factor eif-2b, translation factor activity, rna binding, translation regulator activity, nucleic acid binding, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 279444.92

構造登録者

Nocek, B.,Hao, Q.,Remarcik, C.,Stoll, V.,Wong, Y.,Sidrauski, C. (登録日: 2020-11-02, 公開日: 2021-07-21, 最終更新日: 2023-10-18)

• 主引用文献: Hao, Q.,Heo, J.M.,Nocek, B.P.,Hicks, K.G.,Stoll, V.S.,Remarcik, C.,Hackett, S.,LeBon, L.,Jain, R.,Eaton, D.,Rutter, J.,Wong, Y.L.,Sidrauski, C.; Sugar phosphate activation of the stress sensor eIF2B.; Nat Commun, 12:3440-3440, 2021; PubMed: 34103529; DOI: 10.1038/s41467-021-23836-z

実験手法

X-RAY DIFFRACTION (2.7 Å)