Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7KMA

Crystal structure of eif2Balpha with a ligand.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002183	biological_process	cytoplasmic translational initiation
A	0003743	molecular_function	translation initiation factor activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
A	0005886	cellular_component	plasma membrane
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0009408	biological_process	response to heat
A	0009749	biological_process	response to glucose
A	0014003	biological_process	oligodendrocyte development
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
A	0043434	biological_process	response to peptide hormone
A	0044237	biological_process	cellular metabolic process
A	0050852	biological_process	T cell receptor signaling pathway
B	0002183	biological_process	cytoplasmic translational initiation
B	0003743	molecular_function	translation initiation factor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
B	0005886	cellular_component	plasma membrane
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0009408	biological_process	response to heat
B	0009749	biological_process	response to glucose
B	0014003	biological_process	oligodendrocyte development
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
B	0043434	biological_process	response to peptide hormone
B	0044237	biological_process	cellular metabolic process
B	0050852	biological_process	T cell receptor signaling pathway
C	0002183	biological_process	cytoplasmic translational initiation
C	0003743	molecular_function	translation initiation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
C	0005886	cellular_component	plasma membrane
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0009408	biological_process	response to heat
C	0009749	biological_process	response to glucose
C	0014003	biological_process	oligodendrocyte development
C	0016020	cellular_component	membrane
C	0042802	molecular_function	identical protein binding
C	0043434	biological_process	response to peptide hormone
C	0044237	biological_process	cellular metabolic process
C	0050852	biological_process	T cell receptor signaling pathway
D	0002183	biological_process	cytoplasmic translational initiation
D	0003743	molecular_function	translation initiation factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
D	0005886	cellular_component	plasma membrane
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0009408	biological_process	response to heat
D	0009749	biological_process	response to glucose
D	0014003	biological_process	oligodendrocyte development
D	0016020	cellular_component	membrane
D	0042802	molecular_function	identical protein binding
D	0043434	biological_process	response to peptide hormone
D	0044237	biological_process	cellular metabolic process
D	0050852	biological_process	T cell receptor signaling pathway
E	0002183	biological_process	cytoplasmic translational initiation
E	0003743	molecular_function	translation initiation factor activity
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
E	0005886	cellular_component	plasma membrane
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0009408	biological_process	response to heat
E	0009749	biological_process	response to glucose
E	0014003	biological_process	oligodendrocyte development
E	0016020	cellular_component	membrane
E	0042802	molecular_function	identical protein binding
E	0043434	biological_process	response to peptide hormone
E	0044237	biological_process	cellular metabolic process
E	0050852	biological_process	T cell receptor signaling pathway
F	0002183	biological_process	cytoplasmic translational initiation
F	0003743	molecular_function	translation initiation factor activity
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
F	0005886	cellular_component	plasma membrane
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0009408	biological_process	response to heat
F	0009749	biological_process	response to glucose
F	0014003	biological_process	oligodendrocyte development
F	0016020	cellular_component	membrane
F	0042802	molecular_function	identical protein binding
F	0043434	biological_process	response to peptide hormone
F	0044237	biological_process	cellular metabolic process
F	0050852	biological_process	T cell receptor signaling pathway
G	0002183	biological_process	cytoplasmic translational initiation
G	0003743	molecular_function	translation initiation factor activity
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
G	0005886	cellular_component	plasma membrane
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
G	0009408	biological_process	response to heat
G	0009749	biological_process	response to glucose
G	0014003	biological_process	oligodendrocyte development
G	0016020	cellular_component	membrane
G	0042802	molecular_function	identical protein binding
G	0043434	biological_process	response to peptide hormone
G	0044237	biological_process	cellular metabolic process
G	0050852	biological_process	T cell receptor signaling pathway
H	0002183	biological_process	cytoplasmic translational initiation
H	0003743	molecular_function	translation initiation factor activity
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
H	0005886	cellular_component	plasma membrane
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
H	0009408	biological_process	response to heat
H	0009749	biological_process	response to glucose
H	0014003	biological_process	oligodendrocyte development
H	0016020	cellular_component	membrane
H	0042802	molecular_function	identical protein binding
H	0043434	biological_process	response to peptide hormone
H	0044237	biological_process	cellular metabolic process
H	0050852	biological_process	T cell receptor signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue M6P A 401

Chain	Residue
A	ALA129
A	LYS209
A	LYS234
A	HOH503
A	TYR130
A	SER131
A	ARG132
A	VAL133
A	GLY196
A	ALA197
A	GLU198
A	ASN208

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 402

Chain	Residue
A	ASP19
A	ARG108
A	ARG136
B	HIS170

site_id	AC3
Number of Residues	11
Details	binding site for residue M6P B 401

Chain	Residue
B	TYR130
B	SER131
B	ARG132
B	VAL133
B	GLY196
B	ALA197
B	GLU198
B	ASN208
B	LYS209
B	LYS234
B	HOH502

site_id	AC4
Number of Residues	12
Details	binding site for residue M6P C 401

Chain	Residue
C	HIS128
C	ALA129
C	TYR130
C	SER131
C	ARG132
C	VAL133
C	GLY196
C	GLU198
C	ASN208
C	LYS209
C	LYS234
C	HOH503

site_id	AC5
Number of Residues	10
Details	binding site for residue M6P D 401

Chain	Residue
D	HIS128
D	TYR130
D	SER131
D	ARG132
D	VAL133
D	GLY196
D	ALA197
D	GLU198
D	ASN208
D	LYS234

site_id	AC6
Number of Residues	11
Details	binding site for residue M6P E 401

Chain	Residue
E	HIS128
E	ALA129
E	TYR130
E	SER131
E	ARG132
E	VAL133
E	GLY196
E	ALA197
E	GLU198
E	ASN208
E	LYS234

site_id	AC7
Number of Residues	11
Details	binding site for residue M6P F 401

Chain	Residue
F	HIS128
F	TYR130
F	SER131
F	ARG132
F	VAL133
F	GLY196
F	ALA197
F	GLU198
F	ASN208
F	LYS209
F	LYS234

site_id	AC8
Number of Residues	10
Details	binding site for residue M6P G 401

Chain	Residue
G	ALA129
G	TYR130
G	SER131
G	ARG132
G	VAL133
G	GLY196
G	GLU198
G	ASN208
G	LYS209
G	LYS234

site_id	AC9
Number of Residues	12
Details	binding site for residue M6P H 401

Chain	Residue
H	HIS128
H	ALA129
H	TYR130
H	SER131
H	ARG132
H	VAL133
H	GLY196
H	ALA197
H	GLU198
H	ASN208
H	LYS234
H	HOH507

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS35
B	LYS35
C	LYS35
D	LYS35
E	LYS35
F	LYS35
G	LYS35
H	LYS35

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)