7JPE

Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with m7GpppA Cap-0 and SAM Determined by Fixed-Target Serial Crystallography

Summary for 7JPE

• Entry DOI: 10.2210/pdb7jpe/pdb
• Related: 6W4H 6WJT 6WKQ 6WQ3 6WRZ 6WVN 6XKM 7JHE 7JIB
• Descriptor: 2'-O-methyltransferase, Non-structural protein 10, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: sars cov-2, serial crystallography, methyltransferase, m7gpppa, cap-0, s-adenosylhomomethionine, structural genomics, center for structural genomics of infectious diseases, csgid, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 2
• Total formula weight: 50477.63

Authors

Wilamowski, M.,Sherrell, D.A.,Minasov, G.,Kim, Y.,Shuvalova, L.,Lavens, A.,Chard, R.,Rosas-Lemus, M.,Maltseva, N.,Jedrzejczak, R.,Michalska, K.,Satchell, K.J.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-08-07, release date: 2020-08-26, Last modification date: 2024-02-28)

• Primary citation: Wilamowski, M.,Sherrell, D.A.,Minasov, G.,Kim, Y.,Shuvalova, L.,Lavens, A.,Chard, R.,Maltseva, N.,Jedrzejczak, R.,Rosas-Lemus, M.,Saint, N.,Foster, I.T.,Michalska, K.,Satchell, K.J.F.,Joachimiak, A.; 2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33972410; DOI: 10.1073/pnas.2100170118

Experimental method

X-RAY DIFFRACTION (2.18 Å)