6WQ3

Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-adenosyl-L-homocysteine.

Summary for 6WQ3

Entry DOI	10.2210/pdb6wq3/pdb
Descriptor	2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYL-L-HOMOCYSTEINE, ... (8 entities in total)
Functional Keywords	structural genomics, center for structural genomics of infectious diseases, csgid, nsp16, nsp10, complex, 7-methyl-gpppa, s-adenosyl-l-homocysteine, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More
Total number of polymer chains	2
Total formula weight	51232.10
Authors	Minasov, G.,Shuvalova, L.,Rosas-Lemus, M.,Brunzelle, J.S.,Kiryukhina, O.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-04-28, release date: 2020-05-06, Last modification date: 2024-02-28)
Primary citation	Rosas-Lemus, M.,Minasov, G.,Shuvalova, L.,Inniss, N.L.,Kiryukhina, O.,Brunzelle, J.,Satchell, K.J.F. High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. Sci.Signal., 13:-, 2020 Cited by PubMed: 32994211 DOI: 10.1126/scisignal.abe1202 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation