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7F3O

Crystal structure of the GluA2o LBD in complex with glutamate and TAK-653

Summary for 7F3O
Entry DOI10.2210/pdb7f3o/pdb
DescriptorGlutamate receptor 2, GLUTAMIC ACID, 7-(4-cyclohexyloxyphenyl)-9-methyl-4$l^{6}-thia-1$l^{4},5,8-triazabicyclo[4.4.0]deca-1(10),6,8-triene 4,4-dioxide, ... (7 entities in total)
Functional Keywordsampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains6
Total formula weight179104.62
Authors
Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2021-06-16, release date: 2021-07-28, Last modification date: 2023-11-29)
Primary citationSuzuki, A.,Kunugi, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Toyofuku, M.,Kuno, H.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H.
Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Sci Rep, 11:14532-14532, 2021
Cited by
PubMed: 34267258
DOI: 10.1038/s41598-021-93888-0
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.44 Å)
Structure validation

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