7F3O

Crystal structure of the GluA2o LBD in complex with glutamate and TAK-653

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Glutamate receptor 2	polymer	263	29337.8	6	UniProt (P42262) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Homo sapiens (Human)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	F, A, B, C, D...	GLUTAMIC ACID	non-polymer		147.1	6	Chemie (GLU)
3	A, C, E	7-(4-cyclohexyloxyphenyl)-9-methyl-4$l^{6}-thia-1$l^{4},5,8-triazabicyclo[4.4.0]deca-1(10),6,8-triene 4,4-dioxide	non-polymer		373.5	3	Chemie (0YK)
4	F, B, C, D, E	ZINC ION	non-polymer		65.4	10	Chemie (ZN)
5	F, C, D	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
6	C, D	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7		water	water		18.0	1335	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 413 - 527 (UniProt: P42262)

PDB	External Database	Details
Gly 411	-	expression tag
Ser 412	-	expression tag

A, B, C, D, E, F: 653 - 796 (UniProt: P42262)

PDB	External Database	Details
Gly 641	-	linker
Thr 642	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	176027.0
Non-Polymers*	Number of molecules	25
	Total formula weight	3077.6
All*	Total formula weight	179104.6

*Water molecules are not included.