7DC8

Crystal structure of Switch Ab Fab and hIL6R in complex with ATP

Summary for 7DC8

Entry DOI	10.2210/pdb7dc8/pdb
Descriptor	Switch Ab Fab light chain, Switch Ab Fab heavy chain, Interleukin-6 receptor subunit alpha, ... (6 entities in total)
Functional Keywords	antibody, complex, fab, immune system, cytokine
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	147116.62
Authors	Kadono, S.,Fukami, T.A.,Kawauchi, H.,Torizawa, T.,Mimoto, F. (deposition date: 2020-10-23, release date: 2021-01-13, Last modification date: 2023-11-29)
Primary citation	Mimoto, F.,Tatsumi, K.,Shimizu, S.,Kadono, S.,Haraya, K.,Nagayasu, M.,Suzuki, Y.,Fujii, E.,Kamimura, M.,Hayasaka, A.,Kawauchi, H.,Ohara, K.,Matsushita, M.,Baba, T.,Susumu, H.,Sakashita, T.,Muraoka, T.,Aso, K.,Katada, H.,Tanaka, E.,Nakagawa, K.,Hasegawa, M.,Ayabe, M.,Yamamoto, T.,Tanba, S.,Ishiguro, T.,Kamikawa, T.,Nambu, T.,Kibayashi, T.,Azuma, Y.,Tomii, Y.,Kato, A.,Ozeki, K.,Murao, N.,Endo, M.,Kikuta, J.,Kamata-Sakurai, M.,Ishii, M.,Hattori, K.,Igawa, T. Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment. Cell Rep, 33:108542-108542, 2020 Cited by PubMed: 33357423 DOI: 10.1016/j.celrep.2020.108542 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.757 Å)

Structure validation