7DC8
Crystal structure of Switch Ab Fab and hIL6R in complex with ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Switch Ab Fab light chain | polymer | 216 | 22824.3 | 2 | Homo sapiens (Human) | ||
| 2 | B, E (B, E) | Switch Ab Fab heavy chain | polymer | 230 | 24744.7 | 2 | Homo sapiens (Human) | ||
| 3 | C, F (C, F) | Interleukin-6 receptor subunit alpha | polymer | 218 | 25001.8 | 2 | UniProt (P08887) Pfam (PF09240) | Homo sapiens (Human) | IL-6RA,IL-6R 1,Membrane glycoprotein 80,gp80 |
| 4 | G, I, J, K, L... (A, B, C, D, E...) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 5 | H, O (B, E) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 6 | S, T, U, V, W... (A, B, C, D, E...) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
C, F: 111 - 320 (UniProt: P08887)
| PDB | External Database | Details |
|---|---|---|
| Ser 193 | Cys 193 | engineered mutation |
| Asp 321 | - | expression tag |
| Tyr 322 | - | expression tag |
| Lys 323 | - | expression tag |
| Asp 324 | - | expression tag |
| Asp 325 | - | expression tag |
| Asp 326 | - | expression tag |
| Asp 327 | - | expression tag |
| Lys 328 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 145141.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1975.0 | |
| All* | Total formula weight | 147116.6 |
