7DC8

Crystal structure of Switch Ab Fab and hIL6R in complex with ATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Switch Ab Fab light chain	polymer	216	22824.3	2		Homo sapiens (Human)
2	B, E	Switch Ab Fab heavy chain	polymer	230	24744.7	2		Homo sapiens (Human)
3	C, F	Interleukin-6 receptor subunit alpha	polymer	218	25001.8	2	UniProt (P08887) Pfam (PF09240) In PDB	Homo sapiens (Human)	IL-6RA,IL-6R 1,Membrane glycoprotein 80,gp80
4	A, B, C, D, E...	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
5	B, E	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
6		water	water		18.0	63	Chemie (HOH)

Sequence modifications

C, F: 111 - 320 (UniProt: P08887)

PDB	External Database	Details
Ser 193	Cys 193	engineered mutation
Asp 321	-	expression tag
Tyr 322	-	expression tag
Lys 323	-	expression tag
Asp 324	-	expression tag
Asp 325	-	expression tag
Asp 326	-	expression tag
Asp 327	-	expression tag
Lys 328	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	145141.6
Non-Polymers*	Number of molecules	12
	Total formula weight	1975.0
All*	Total formula weight	147116.6

*Water molecules are not included.