7DC8

Crystal structure of Switch Ab Fab and hIL6R in complex with ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 301

Chain	Residue
A	GLU83
A	THR105
A	VAL106
A	TYR141
A	LYS167
A	TYR173
A	HOH403

---

site_id	AC2
Number of Residues	15
Details	binding site for residue ATP B 301

Chain	Residue
B	SER52
B	GLN53
B	SER54
B	TYR55
B	HIS56
B	TYR95
B	GLY96
B	LEU98
B	LEU100
B	ASN100
B	TRP100
B	HOH401
C	PHE298
B	THR33
B	SER52

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 B 302

Chain	Residue
B	PHE27
B	THR28
B	TYR32

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 303

Chain	Residue
B	LYS13
B	ARG71
B	ASP72
B	ASN73

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 C 401

Chain	Residue
C	GLN274
C	HIS275

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 C 402

Chain	Residue
C	ARG293
C	GLU302
C	TRP303
F	PHE202

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 D 301

Chain	Residue
D	GLU83
D	TYR141
D	LYS167
D	TYR173
D	HOH409

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 D 302

Chain	Residue
D	SER67
D	GLY68

---

site_id	AC9
Number of Residues	18
Details	binding site for residue ATP E 301

Chain	Residue
E	THR33
E	SER52
E	SER52
E	GLN53
E	SER54
E	TYR55
E	HIS56
E	TYR95
E	GLY96
E	LEU98
E	LEU100
E	ASN100
E	TRP100
E	HOH404
E	HOH405
E	HOH406
E	HOH407
F	PHE298

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 E 302

Chain	Residue
E	PHE27
E	THR28
E	TYR32

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 F 401

Chain	Residue
F	LEU273
F	GLN274
F	HIS275
F	HIS276

---

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 F 402

Chain	Residue
C	PHE202
F	ARG293
F	TRP303

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR194-HIS200
A	TYR192-HIS198

---

site_id	PS01354
Number of Residues	42
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LqPDPPanItvtavarnprwLsvtWqdPhSWnssf..YrLrFeL

Chain	Residue	Details
C	LEU214-LEU255

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	196
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"10066782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10066782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28060820","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28060820","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---