7D7S

HIV-1 SF2 Nef in complex with the Fyn SH3 R96I mutant

Summary for 7D7S

Entry DOI	10.2210/pdb7d7s/pdb
Related	3H0F 3H0H 3H0I 4d8d 6IPY 6IPZ
Descriptor	Protein Nef, Tyrosine-protein kinase Fyn (2 entities in total)
Functional Keywords	complex, mutant, kinase, sh3, viral protein
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) More
Total number of polymer chains	4
Total formula weight	67681.65
Authors	Aldehaiman, A.,Shahul Hamed, U.F.,Arold, S.T. (deposition date: 2020-10-05, release date: 2020-11-18, Last modification date: 2023-11-29)
Primary citation	Aldehaiman, A.,Momin, A.A.,Restouin, A.,Wang, L.,Shi, X.,Aljedani, S.,Opi, S.,Lugari, A.,Shahul Hameed, U.F.,Ponchon, L.,Morelli, X.,Huang, M.,Dumas, C.,Collette, Y.,Arold, S.T. Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478:1525-1545, 2021 Cited by PubMed: 33787846 DOI: 10.1042/BCJ20201002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.32 Å)

Structure validation