7D7S

HIV-1 SF2 Nef in complex with the Fyn SH3 R96I mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0006915	biological_process	apoptotic process
A	0007171	biological_process	activation of transmembrane receptor protein tyrosine kinase activity
A	0016020	cellular_component	membrane
A	0017124	molecular_function	SH3 domain binding
A	0019049	biological_process	virus-mediated perturbation of host defense response
A	0020002	cellular_component	host cell plasma membrane
A	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
A	0039521	biological_process	suppression by virus of host autophagy
A	0044177	cellular_component	host cell Golgi apparatus
A	0044178	cellular_component	host cell Golgi membrane
A	0044423	cellular_component	virion component
A	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
A	0075509	biological_process	endocytosis involved in viral entry into host cell
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005576	cellular_component	extracellular region
B	0006915	biological_process	apoptotic process
B	0007171	biological_process	activation of transmembrane receptor protein tyrosine kinase activity
B	0016020	cellular_component	membrane
B	0017124	molecular_function	SH3 domain binding
B	0019049	biological_process	virus-mediated perturbation of host defense response
B	0020002	cellular_component	host cell plasma membrane
B	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
B	0039521	biological_process	suppression by virus of host autophagy
B	0044177	cellular_component	host cell Golgi apparatus
B	0044178	cellular_component	host cell Golgi membrane
B	0044423	cellular_component	virion component
B	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
B	0075509	biological_process	endocytosis involved in viral entry into host cell

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Might play a role in AP-1 recruitment to the Nef-MHC-I complex => ECO:0000255|HAMAP-Rule:MF_04078

Chain	Residue	Details
A	MET20
B	MET20

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by viral protease => ECO:0000255|HAMAP-Rule:MF_04078

Chain	Residue	Details
A	TRP61
B	TRP61

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04078, ECO:0000269|PubMed:17904606

Chain	Residue	Details
A	SER6
B	SER6

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site_id	SWS_FT_FI4
Number of Residues	2
Details	LIPID: N-myristoyl glycine; by host => ECO:0000255|HAMAP-Rule:MF_04078

Chain	Residue	Details
A	GLY2
B	GLY2

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