7D7S

HIV-1 SF2 Nef in complex with the Fyn SH3 R96I mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0007171	biological_process	activation of transmembrane receptor protein tyrosine kinase activity
A	0016020	cellular_component	membrane
A	0017124	molecular_function	SH3 domain binding
A	0019058	biological_process	viral life cycle
A	0020002	cellular_component	host cell plasma membrane
A	0039504	biological_process	symbiont-mediated suppression of host adaptive immune response
A	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
A	0044178	cellular_component	host cell Golgi membrane
A	0044423	cellular_component	virion component
A	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
A	0051246	biological_process	regulation of protein metabolic process
A	0051701	biological_process	biological process involved in interaction with host
A	0052031	biological_process	symbiont-mediated perturbation of host defense response
A	0075509	biological_process	endocytosis involved in viral entry into host cell
A	0140321	biological_process	symbiont-mediated suppression of host autophagy
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005576	cellular_component	extracellular region
B	0007171	biological_process	activation of transmembrane receptor protein tyrosine kinase activity
B	0016020	cellular_component	membrane
B	0017124	molecular_function	SH3 domain binding
B	0019058	biological_process	viral life cycle
B	0020002	cellular_component	host cell plasma membrane
B	0039504	biological_process	symbiont-mediated suppression of host adaptive immune response
B	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
B	0044178	cellular_component	host cell Golgi membrane
B	0044423	cellular_component	virion component
B	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
B	0051246	biological_process	regulation of protein metabolic process
B	0051701	biological_process	biological process involved in interaction with host
B	0052031	biological_process	symbiont-mediated perturbation of host defense response
B	0075509	biological_process	endocytosis involved in viral entry into host cell
B	0140321	biological_process	symbiont-mediated suppression of host autophagy

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Region: {"description":"Mediates dimerization, Nef-PTE1 interaction","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"PxxP; stabilizes the interaction of NEF/MHC-I with host AP1M1; necessary for MHC-I internalization","evidences":[{"source":"HAMAP-Rule","id":"MF_04078","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---