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7AVV

Crystal structure of SOS1 in complex with compound 9

Summary for 7AVV
Entry DOI10.2210/pdb7avv/pdb
Related7AVI 7AVL 7AVS 7AVT 7AVU
DescriptorSon of sevenless homolog 1, IMIDAZOLE, ~{N}-[(1~{R})-1-[3-azanyl-5-(trifluoromethyl)phenyl]ethyl]-2-methyl-quinazolin-4-amine, ... (4 entities in total)
Functional Keywordsrasgef, protein binding
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight57518.72
Authors
Bader, G.,Kessler, D.,Wolkerstorfer, B. (deposition date: 2020-11-06, release date: 2021-03-24, Last modification date: 2024-01-31)
Primary citationRamharter, J.,Kessler, D.,Ettmayer, P.,Hofmann, M.H.,Gerstberger, T.,Gmachl, M.,Wunberg, T.,Kofink, C.,Sanderson, M.,Arnhof, H.,Bader, G.,Rumpel, K.,Zophel, A.,Schnitzer, R.,Bottcher, J.,O'Connell, J.C.,Mendes, R.L.,Richard, D.,Pototschnig, N.,Weiner, I.,Hela, W.,Hauer, K.,Haering, D.,Lamarre, L.,Wolkerstorfer, B.,Salamon, C.,Werni, P.,Munico-Martinez, S.,Meyer, R.,Kennedy, M.D.,Kraut, N.,McConnell, D.B.
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.
J.Med.Chem., 64:6569-6580, 2021
Cited by
PubMed: 33719426
DOI: 10.1021/acs.jmedchem.0c01949
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.12 Å)
Structure validation

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