7AVI
Crystal structure of SOS1 in complex with compound 2
Summary for 7AVI
Entry DOI | 10.2210/pdb7avi/pdb |
Descriptor | Son of sevenless homolog 1, 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide (3 entities in total) |
Functional Keywords | rasgef, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 114983.45 |
Authors | Bader, G.,Kessler, D.,Wolkerstorfer, B. (deposition date: 2020-11-05, release date: 2021-03-24, Last modification date: 2024-01-31) |
Primary citation | Ramharter, J.,Kessler, D.,Ettmayer, P.,Hofmann, M.H.,Gerstberger, T.,Gmachl, M.,Wunberg, T.,Kofink, C.,Sanderson, M.,Arnhof, H.,Bader, G.,Rumpel, K.,Zophel, A.,Schnitzer, R.,Bottcher, J.,O'Connell, J.C.,Mendes, R.L.,Richard, D.,Pototschnig, N.,Weiner, I.,Hela, W.,Hauer, K.,Haering, D.,Lamarre, L.,Wolkerstorfer, B.,Salamon, C.,Werni, P.,Munico-Martinez, S.,Meyer, R.,Kennedy, M.D.,Kraut, N.,McConnell, D.B. One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS. J.Med.Chem., 64:6569-6580, 2021 Cited by PubMed: 33719426DOI: 10.1021/acs.jmedchem.0c01949 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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