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7AVI

Crystal structure of SOS1 in complex with compound 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0007264biological_processsmall GTPase-mediated signal transduction
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0007264biological_processsmall GTPase-mediated signal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue S2Q A 1101
ChainResidue
AMET878
AASN879
ATYR884
APHE890
ALYS898
ALEU901
AGLU902
AHIS905

site_idAC2
Number of Residues8
Detailsbinding site for residue S2Q B 1101
ChainResidue
BTYR884
BPHE890
BLYS898
BLEU901
BGLU902
BHIS905
BHOH1394
BASN879

Functional Information from PROSITE/UniProt
site_idPS00720
Number of Residues34
DetailsRASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK
ChainResidueDetails
AVAL927-LYS960

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PDB entries from 2024-06-12

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