7AVI

Crystal structure of SOS1 in complex with compound 2

Summary for 7AVI

• Entry DOI: 10.2210/pdb7avi/pdb
• Descriptor: Son of sevenless homolog 1, 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide (3 entities in total)
• Functional Keywords: rasgef, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 114983.45

Authors

Bader, G.,Kessler, D.,Wolkerstorfer, B. (deposition date: 2020-11-05, release date: 2021-03-24, Last modification date: 2024-01-31)

• Primary citation: Ramharter, J.,Kessler, D.,Ettmayer, P.,Hofmann, M.H.,Gerstberger, T.,Gmachl, M.,Wunberg, T.,Kofink, C.,Sanderson, M.,Arnhof, H.,Bader, G.,Rumpel, K.,Zophel, A.,Schnitzer, R.,Bottcher, J.,O'Connell, J.C.,Mendes, R.L.,Richard, D.,Pototschnig, N.,Weiner, I.,Hela, W.,Hauer, K.,Haering, D.,Lamarre, L.,Wolkerstorfer, B.,Salamon, C.,Werni, P.,Munico-Martinez, S.,Meyer, R.,Kennedy, M.D.,Kraut, N.,McConnell, D.B.; One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.; J.Med.Chem., 64:6569-6580, 2021; PubMed: 33719426; DOI: 10.1021/acs.jmedchem.0c01949

Experimental method

X-RAY DIFFRACTION (1.93 Å)