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7AVI

Crystal structure of SOS1 in complex with compound 2

Summary for 7AVI
Entry DOI10.2210/pdb7avi/pdb
DescriptorSon of sevenless homolog 1, 3-propan-2-yl-~{N}-[(1~{R})-1-(3-sulfamoylphenyl)ethyl]-[1,2]oxazolo[5,4-b]pyridine-5-carboxamide (3 entities in total)
Functional Keywordsrasgef, protein binding
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight114983.45
Authors
Bader, G.,Kessler, D.,Wolkerstorfer, B. (deposition date: 2020-11-05, release date: 2021-03-24, Last modification date: 2024-01-31)
Primary citationRamharter, J.,Kessler, D.,Ettmayer, P.,Hofmann, M.H.,Gerstberger, T.,Gmachl, M.,Wunberg, T.,Kofink, C.,Sanderson, M.,Arnhof, H.,Bader, G.,Rumpel, K.,Zophel, A.,Schnitzer, R.,Bottcher, J.,O'Connell, J.C.,Mendes, R.L.,Richard, D.,Pototschnig, N.,Weiner, I.,Hela, W.,Hauer, K.,Haering, D.,Lamarre, L.,Wolkerstorfer, B.,Salamon, C.,Werni, P.,Munico-Martinez, S.,Meyer, R.,Kennedy, M.D.,Kraut, N.,McConnell, D.B.
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.
J.Med.Chem., 64:6569-6580, 2021
Cited by
PubMed: 33719426
DOI: 10.1021/acs.jmedchem.0c01949
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

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