7AB0
Apo crystal structure of the MerTK kinase domain
Summary for 7AB0
Entry DOI | 10.2210/pdb7ab0/pdb |
Related | 7AAX 7AAY 7AAZ |
Descriptor | Tyrosine-protein kinase Mer, CHLORIDE ION (3 entities in total) |
Functional Keywords | tyrosine kinase, apo, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34559.02 |
Authors | Pflug, A.,Schimpl, M.,McCoull, W.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J. (deposition date: 2020-09-05, release date: 2020-10-28, Last modification date: 2024-01-31) |
Primary citation | Pflug, A.,Schimpl, M.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,McCoull, W. A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477:4443-4452, 2020 Cited by PubMed: 33119085DOI: 10.1042/BCJ20200735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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